Abstract
Longifolicin (1), longicoricin (2) and (2,4-cis and trans)-gigantetroneninone (3), three novel bioactive mono-tetra-hydrofuran (THF) gamma-lactone acetogenins, were isolated from the leaves and twigs of Asimina longifolia (Annonaceae) by directing the fractionation with the brine shrimp lethality test (BST). The structures were elucidated based on spectroscopic and chemical methods. Compounds 1-3 showed selective and potent cytotoxicities to certain human tumor cell lines.
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Animals
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Antineoplastic Agents, Phytogenic / chemistry
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Antineoplastic Agents, Phytogenic / isolation & purification*
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Antineoplastic Agents, Phytogenic / toxicity
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Artemia
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Furans / chemistry
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Furans / isolation & purification*
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Furans / toxicity
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Gas Chromatography-Mass Spectrometry
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Humans
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Lactones / chemistry
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Lactones / isolation & purification*
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Lactones / toxicity
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Magnetic Resonance Spectroscopy
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Plant Leaves / chemistry
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Trees / chemistry*
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Tumor Cells, Cultured
Substances
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Antineoplastic Agents, Phytogenic
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Furans
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Lactones
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longicoricin
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longifolicin
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gigantetroneninone