Cellular signalling: the role of the peroxisome

Cell Signal. 1996 Mar;8(3):197-208. doi: 10.1016/0898-6568(95)02055-1.


This article reviews the role of the peroxisome in cellular signalling, with particular emphasis on the unique contributions of this organelle to the complex regulatory inter-relationships of cellular processes within the mammalian organism. Among the topics covered are the close alignments between the signalling systems governing peroxisome proliferation and those of the steroid hormone/thyroid hormone/vitamin D nuclear-receptor superfamily; the regulation of the permeability of the peroxisomal membrane; the involvements of lysophosphatidic acid as an intra- and inter-cellular messenger; the special role of the phosphatidylcholine cycle and its derivative messengers in relation to peroxisomal metabolism; peroxisomal contributions to the regulation of oxygen free radical levels in tissues and the significance of these radicals as second messengers; the evidence of peroxisomal influences on inter-cellular signalling from metabolic turnover studies; modifications of the regulatory significance of fatty acids by the peroxisome; the commonalities in metabolic relationships between the peroxisome and other cellular organelles; and regulatory shuttles associated with peroxisomal function. It is concluded that the peroxisome displays several significant interconnections with the cellular-signalling apparatus, that it is capable of imprinting a characteristic influence on the regulatory network in the cell, and that the contributions of this organelle deserve greater consideration in future investigations of cell-signalling phenomena.

Publication types

  • Review

MeSH terms

  • Animals
  • Cell Membrane
  • Free Radicals
  • Hydrogen Peroxide / metabolism
  • Lysophospholipids / metabolism
  • Microbodies / metabolism*
  • Oxygen
  • Phosphatidylcholines / metabolism
  • Signal Transduction / physiology*


  • Free Radicals
  • Lysophospholipids
  • Phosphatidylcholines
  • Hydrogen Peroxide
  • Oxygen