Abstract
Protein 90K is a tumor-associated antigen, which is able to enhance the cytotoxic activity in lymphokine-activated and natural killer cells as well as the IL-2 release in peripheral blood lymphocytes. In our in vitro experiences we observed a stimulatory effect by IFN-alpha and IFN-gamma on 90K-specific mRNA expression and protein release in ovarian cancer cells, and 90K was furthermore found to be a potent stimulator of macrophage activity. Protein 90K seems to be involved in tumor immunology; it may represent a critical link between tumor and immune system.
MeSH terms
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Adjuvants, Immunologic / physiology*
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Antigens, Neoplasm / physiology*
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Cell Line
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Cytotoxicity, Immunologic / immunology*
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Female
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Gene Expression Regulation, Neoplastic / physiology
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Humans
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Interferon-alpha / physiology
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Interferon-gamma / physiology
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Interleukin-2 / physiology
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Killer Cells, Lymphokine-Activated / immunology*
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Killer Cells, Natural / immunology*
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Lymphocyte Activation / physiology
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Neoplasm Proteins / physiology*
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Ovarian Neoplasms / genetics
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Ovarian Neoplasms / immunology*
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RNA, Messenger / genetics
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Tumor Cells, Cultured / immunology
Substances
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Adjuvants, Immunologic
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Antigens, Neoplasm
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Interferon-alpha
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Interleukin-2
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Neoplasm Proteins
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RNA, Messenger
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ovarian tumor associated antigen
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Interferon-gamma