Inhibition of rat mast cell degranulation and histamine release by histamine-rat gammaglobulin conjugate

Int Arch Allergy Appl Immunol. 1979;59(4):403-7. doi: 10.1159/000232287.


Histamin-rat-gamma-globulin conjugate inhibited degranulation and histamine release of rat peritoneal mast cells to a greater extent than the rat globulin or histamine alone. Since mast cells contain histamine receptors, it may be assumed that the histamine bound to the gamma-globulin combines with the rat mast cell histamine receptor and inhibits the degranulation and histamine release by a feedback mechanism.

MeSH terms

  • Animals
  • Cytoplasmic Granules / drug effects
  • Female
  • Histamine / metabolism
  • Histamine / pharmacology*
  • Histamine Release / drug effects*
  • Mast Cells / drug effects*
  • Mast Cells / physiology
  • Rats
  • Receptors, Histamine / metabolism
  • gamma-Globulins / metabolism
  • gamma-Globulins / pharmacology


  • Receptors, Histamine
  • gamma-Globulins
  • Histamine