Transgenic mouse models of breast cancer

Breast Cancer Res Treat. 1996;39(1):119-35. doi: 10.1007/BF01806083.


Although valuable initial information can be gathered about transformation from in vitro studies, human cancer occurs in the context of a complex interaction with its environment and must ultimately be studied in living animals. Transgenic animal models have been used to study breast transformation for a number of years and have yielded valuable information on the subject. In this paper, we will summarize results from our laboratories, and others, regarding the use of transgenic mice to study breast tumorigenesis. We will also suggest future directions for the use of transgenic models to understand, and hopefully, one day to cure the disease.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Review

MeSH terms

  • Animals
  • Breast Neoplasms* / genetics
  • Breast Neoplasms* / metabolism
  • Disease Models, Animal*
  • Female
  • Forecasting
  • Humans
  • Mice
  • Mice, Transgenic*
  • Oncogene Proteins, Viral / metabolism
  • Proto-Oncogene Proteins c-myc / metabolism
  • Transforming Growth Factor alpha / metabolism


  • Oncogene Proteins, Viral
  • Proto-Oncogene Proteins c-myc
  • Transforming Growth Factor alpha