A clinical profile of corticobasal degeneration presenting as primary progressive aphasia

Eur Neurol. 1996;36(3):134-7. doi: 10.1159/000117229.


We report a patient with primary progressive aphasia who first presented with amnesic aphasia that developed over the course of 3 years into nonfluent aphasia with buccofacial apraxia, followed in the next year by cognitive impairment and parkinsonism. Pathological findings were typical for corticobasal degeneration except for the distribution of cortical atrophy. This case suggests that corticobasal degeneration should be included in the differential diagnosis of primary progressive aphasia, especially in association with parkinsonism.

Publication types

  • Case Reports

MeSH terms

  • Aphasia, Primary Progressive / etiology*
  • Basal Ganglia / physiology
  • Cerebral Cortex / physiology*
  • Diagnosis, Differential
  • Humans
  • Male
  • Middle Aged
  • Nerve Degeneration / physiology*
  • Substantia Nigra / physiology*