Immunophenotypic profiles of peripheral blood lymphocytes in women with recurrent pregnancy losses and in infertile women with multiple failed in vitro fertilization cycles

Am J Reprod Immunol. 1996 Apr;35(4):376-82. doi: 10.1111/j.1600-0897.1996.tb00497.x.


In summary (1) Nonpregnant women with RSAs of unknown etiology have higher levels of CD56+ lymphocytes when compared to normal controls; (2) The levels of CD19+, CD56+, and CD56+/CD16+ PBL of pregnant women with RSA are significantly higher than those of multiparous pregnant normal controls; (3) Women with autoantibodies to phospholipids have significantly higher levels of elevated CD56+ and CD56+/CD16+ lymphocytes when compared to women without antiphospholipid antibodies; (4) Women with autoantibodies to nuclear components demonstrate higher numbers of CD19+/CD5+ cells compared to women without autoantibodies to nuclear components; (5) Idiopathic infertile women with multiple prior IVF failures demonstrate significantly higher levels of CD56+ pBL than normal fertile controls and the conception rate is much higher in those with CD56+ levels less than 12%; (6) Elevations of CD56+ lymphocytes to over 18% during a pregnancy is a good prognostic indicator of impending pregnancy loss. We have not seen a liveborn infant in women with levels of 18% or higher without IVIg therapy; and (7) Infertile and RSA women who fail alloimmune and autoimmune therapy have significant alterations in cellular and humoral immunity involving NK cells and CD19+/CD5+ B cells.

MeSH terms

  • Abortion, Habitual / immunology*
  • Antibodies, Antiphospholipid / immunology
  • Autoimmunity / immunology
  • B-Lymphocytes / immunology
  • CD5 Antigens / analysis
  • Female
  • Fertilization in Vitro*
  • Humans
  • Immunophenotyping
  • Infertility, Female / immunology*
  • Killer Cells, Natural / immunology
  • Lymphocyte Count
  • Lymphocyte Subsets / classification*
  • Pregnancy


  • Antibodies, Antiphospholipid
  • CD5 Antigens