Serum undercarboxylated osteocalcin is a marker of the risk of hip fracture: a three year follow-up study

Bone. 1996 May;18(5):487-8. doi: 10.1016/8756-3282(96)00037-3.


We have previously shown that elderly women with an increased serum undercarboxylated osteocalcin (ucOC) level have an increased risk of sustaining a hip fracture as compared to those with normal serum ucOC. We reassessed our findings on a larger number of hip fractures that occurred over 3 years in 183 institutionalized women (aged 70-97 years) belonging to a large prospective clinical trial. Total OC, carboxylated OC, ucOC, and alkaline phosphatase were significantly higher at baseline in those who sustained a hip fracture during the follow-up. The age-adjusted odds ratio for hip fracture was three times higher in women with increased ucOC at baseline (odds ratio = 3.1, 99.9% C.I. = 1.7-6.0, p < 0.001). In the logistic regression, ucOC was still predictive of the hip fracture when age and parathyroid hormone concentration were included into the model (odds ratio = 2.6, 95% C.I. = 1.05-6.4). These data confirm that ucOC is a marker of the increased risk of hip fracture in elderly institutionalized women. Serum ucOC may reflect some nutritional deficiency associated with increased bone fragility.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Aged, 80 and over
  • Alkaline Phosphatase / blood
  • Carboxylic Acids / chemistry
  • Cohort Studies
  • Female
  • Follow-Up Studies
  • Hip Fractures / diagnosis
  • Hip Fractures / epidemiology*
  • Hip Fractures / etiology
  • Humans
  • Odds Ratio
  • Osteocalcin / blood*
  • Parathyroid Hormone / blood
  • Regression Analysis
  • Risk Factors


  • Carboxylic Acids
  • Parathyroid Hormone
  • Osteocalcin
  • Alkaline Phosphatase