A possible role for malonyl-CoA in the regulation of hepatic fatty acid oxidation and ketogenesis

J Clin Invest. 1977 Jul;60(1):265-70. doi: 10.1172/JCI108764.


Studied on the oxidation of oleic and octanoic acids to ketone bodies were carried out in homogenates and in mitochondrial fractions of livers taken from fed and fasted rats. Malonyl-CoA inhibited ketogenesis from the former but not from the latter substrate. The site of inhibition appeared to be the carnitine acyltransferase I reaction. The effect was specific and easily reversible. Inhibitory concentrations were in the range of values obtained in livers from fed rats by others. It is proposed that malonyl-CoA functions as both precursor for fatty acid synthesis and suppressor of fatty acid oxidation. As such, it might be an important element in the carbohydrate-induced sparing of fatty acid oxidation.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Caprylates / metabolism
  • Carnitine / analogs & derivatives
  • Carnitine / metabolism
  • Coenzyme A / pharmacology*
  • Coenzyme A / physiology
  • Fatty Acids / metabolism*
  • Ketone Bodies / biosynthesis*
  • Liver / metabolism*
  • Male
  • Malonates
  • Mitochondria, Liver / metabolism
  • Models, Biological
  • Oleic Acids / metabolism
  • Oxidation-Reduction
  • Rats


  • Caprylates
  • Fatty Acids
  • Ketone Bodies
  • Malonates
  • Oleic Acids
  • Carnitine
  • Coenzyme A