Observations on the decay of glycated hemoglobin HbA1c in diabetic patients

Exp Clin Endocrinol Diabetes. 1996;104(2):102-5. doi: 10.1055/s-0029-1211430.

Abstract

In 44 diabetic patients, who within 7 days lowered their average glycemia by 140 to 220 mg % and kept it at this level over a mean of 36 days, HbA1c was measured repeatedly by HPLC (normal range 4.2-5.6% of total hemoglobin). Thereby, the maximum decay rate of HbA1c could be observed in vivo as being 0.1% per day which is consistent with previous theoretical considerations by other authors. Some clinical implications that this finding may have for diabetic patients are being discussed.

MeSH terms

  • Blood Glucose / metabolism*
  • Blood Glucose Self-Monitoring
  • Chromatography, High Pressure Liquid
  • Diabetes Mellitus, Type 1 / blood*
  • Diabetes Mellitus, Type 1 / drug therapy
  • Diabetes Mellitus, Type 2 / blood*
  • Glycated Hemoglobin A / metabolism*
  • Humans
  • Hyperglycemia*
  • Hypoglycemic Agents / therapeutic use*
  • Insulin / therapeutic use*
  • Reference Values
  • Regression Analysis
  • Time Factors

Substances

  • Blood Glucose
  • Glycated Hemoglobin A
  • Hypoglycemic Agents
  • Insulin