The substantiation of views to the foci of the "cryptogenic" infection and its nature in sepsis is given. The state of the redox system, immunological status and functions of the liver and kidneys in patients with complicated sepsis are investigated. The data on the influence of nonmedicamental methods (hemodialysis, AUVIB, HBO, EHS) upon the parameters of the redox system, cellular and humoral immunity in acute sepsis patients are presented. A complex of nonmedicamental methods, most effective in correction of homeostasis disturbances in sepsis is suggested and tested. An analysis of efficiency of each of the nonmedicamental methods has shown that they statistically promote the decreasing of lethality indices and the duration of the hospital treatment.