Transcriptional repression in development

Curr Opin Cell Biol. 1996 Jun;8(3):358-64. doi: 10.1016/s0955-0674(96)80010-x.


It is becoming increasingly clear that transcriptional repression is at least as important as transcriptional activation for establishing cell-type specific patterns of gene expression during embryogenesis. Recent studies in Drosophila suggest that repressors fall into two categories, short-range and long-range repressors. The former permit enhancer autonomy in modular promoters, whereas the latter function in a dominant fashion to silence multiple enhancers.

Publication types

  • Review

MeSH terms

  • Animals
  • Gene Expression Regulation, Developmental / genetics
  • Transcription, Genetic / genetics*