Does this have a familiar RING?

Trends Biochem Sci. 1996 Jun;21(6):208-14.


The RING finger is a zinc-binding domain that is found in proteins from plants to humans, but whose function remains largely enigmatic. The domain itself is distinct from other zinc-finger motifs in terms of sequence homology, zinc-ligation scheme and three-dimensional structure. It appears that the RING is involved in mediating protein-protein interactions and in some cases multi-protein complexes, which might depend on the presence of other proteins and/or domains.

MeSH terms

  • Binding Sites
  • Cysteine / chemistry
  • DNA-Binding Proteins / metabolism
  • Major Histocompatibility Complex
  • Metalloproteins / chemistry*
  • Metalloproteins / metabolism
  • Microbodies / metabolism
  • Models, Molecular
  • Protein Structure, Tertiary
  • Proteins / chemistry
  • Signal Transduction / physiology
  • Zinc / metabolism*
  • Zinc Fingers / genetics*


  • DNA-Binding Proteins
  • Metalloproteins
  • Proteins
  • Zinc
  • Cysteine