Evolution of ATP-binding cassette transporter genes

Curr Opin Genet Dev. 1995 Dec;5(6):779-85. doi: 10.1016/0959-437x(95)80011-s.


The transport of molecules across lipid membranes is an essential function of all living organisms. One of the families of genes that have evolved to carry out this function is that which encodes the ATP-binding cassette proteins. These molecules use active transport to pump specific molecules across membranes, and the genes that encode them are found in abundance in the genomes of both prokaryotes and eukaryotes. By using gene disruption techniques and by studying homologous genes in model organisms, significant progress has been made during the last few years in evaluating the physiological functions of ABC proteins in higher eukaryotes.

Publication types

  • Comparative Study
  • Review

MeSH terms

  • ATP-Binding Cassette Transporters / genetics*
  • Bacterial Proteins / genetics*
  • Biological Evolution*
  • Escherichia coli / genetics
  • Eukaryotic Cells
  • Genes, Bacterial*
  • Genetic Diseases, Inborn / genetics*
  • Herpes Simplex / genetics
  • Humans
  • Multigene Family*


  • ATP-Binding Cassette Transporters
  • Bacterial Proteins