Identification of a glutathione peroxidase homolog in Neisseria meningitidis

DNA Seq. 1995;6(1):55-60. doi: 10.3109/10425179509074701.

Abstract

Glutathione peroxidase is an antioxidant enzyme found in a diverse array of eukaryotic species. We have determined the DNA sequence of a glutathione peroxidase homolog in the pathogenic bacterium Neisseria meningitidis. The sequence displays features of a functional gene, but lacks a selenocysteine-encoding in-frame TGA codon characteristic of most mammalian glutathione peroxidase genes. The derived amino acid sequence encoded by the N. meningitidis homolog predicts a 19.9 kDa protein that displays a high level of amino acid identity with other gluathione peroxidase sequences, particularly within four conserved regions of the enzyme.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Amino Acid Sequence
  • Base Sequence
  • Glutathione Peroxidase / genetics*
  • Molecular Sequence Data
  • Neisseria meningitidis / genetics*
  • Sequence Homology

Substances

  • Glutathione Peroxidase