Suppression of mesangial-cell proliferation by trapidil in glomerulonephritis induced by anti-thymocyte serum in rats

J Int Med Res. 1995 Nov-Dec;23(6):458-66. doi: 10.1177/030006059502300607.


Trapadil (Mochida Pharmaceuticals, Japan), an antiplatelet drug, suppresses the growth of several cell types and is thought to antagonize platelet-derived growth factor. The effects of trapidil on mesangial-cell proliferation in glomerulonephritis induced by anti-thymocyte serum in Wistar rats were investigated. Control rats were treated with phosphate-buffered saline (group I); group II rats were injected with a single dose of anti-thymocyte serum (8 ml/kg body weight), and group III rats were treated with both a single dose of anti-thymocyte serum (8 ml/kg body weight) and with trapidil (5 mg/kg body weight/day). Three rats in each group were killed on day 3, and the other three on day 10. Control rats showed no significant histological changes on day 3 or day 10. In group II, on day 3, there was a marked decrease in glomerular cell numbers, with mesangiolysis. Histologically severe mesangial-cell proliferation with expansion of mesangial areas was noted on day 10. None of the rats in group III showed mesangial alterations, histologically, indicating that mesangial-cell proliferation was suppressed by trapidil. This suppression may result from antagonism of the binding of platelet-derived growth factor to the specific surface receptors in the mesangial cells. Trapidil may have clinical value in the treatment of mesangial-cell proliferative glomerular diseases.

MeSH terms

  • Animals
  • Antilymphocyte Serum*
  • Glomerular Mesangium / drug effects
  • Glomerular Mesangium / pathology*
  • Glomerulonephritis / etiology
  • Glomerulonephritis / pathology*
  • Glomerulonephritis / prevention & control*
  • Kidney Glomerulus / drug effects
  • Kidney Glomerulus / pathology
  • Male
  • Rats
  • Rats, Wistar
  • Time Factors
  • Trapidil / pharmacology*
  • Vasodilator Agents / pharmacology*


  • Antilymphocyte Serum
  • Vasodilator Agents
  • Trapidil