Biologic factors affecting spinal fusion and bone regeneration

Spine (Phila Pa 1976). 1995 Dec 15;20(24 Suppl):102S-112S.


Study design: Literature review.

Objectives: This article reviews the existing data on the multiplicity of local and systemic factors affecting lumbar spinal fusion and the general biology of bone regeneration.

Summary of background data: Arthrodesis is one of the most commonly performed, yet incompletely understood, procedures in spinal surgery. There exists a paucity of knowledge about the basic biology involved in achieving a successful fusion.

Methods: Medline and manual search of all relevant articles were performed and summarized.

Results: The success or failure of spinal fusion may be influenced by a host of local and systemic factors.

Conclusions: Future research should focus on expanding our existing knowledge pertaining to the basic biology of bone regeneration specific to spinal fusion.

Publication types

  • Review

MeSH terms

  • Bone Regeneration / physiology*
  • Humans
  • Spinal Diseases / pathology
  • Spinal Diseases / physiopathology
  • Spinal Diseases / surgery*
  • Spinal Fusion*