Fibrosis causes progressive kidney failure

Med Hypotheses. 1995 Nov;45(5):459-62. doi: 10.1016/0306-9877(95)90221-x.


Fibrosis is usually regarded as an uninteresting end-point of injury. However, it influences function in heart, lung, and liver. Kidney fibrosis correlates well with overall renal function, but is only rarely recognized as affecting function itself. There is evidence that organ contraction from fibrotic scarring may affect kidney function, and could contribute to progressive renal failure.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Angiotensin-Converting Enzyme Inhibitors / therapeutic use
  • Animals
  • Dietary Proteins / administration & dosage
  • Fibrosis
  • Humans
  • Hypertension, Renal / drug therapy
  • Hypertension, Renal / etiology
  • Kidney / pathology*
  • Kidney / physiopathology
  • Kidney Failure, Chronic / etiology*
  • Kidney Failure, Chronic / pathology
  • Kidney Failure, Chronic / therapy
  • Models, Biological*


  • Angiotensin-Converting Enzyme Inhibitors
  • Dietary Proteins