NADPH oxidase and the respiratory burst

Semin Cell Biol. 1995 Dec;6(6):357-65. doi: 10.1016/s1043-4682(05)80006-6.

Abstract

Phagocytic cells possess an electron-transport system which accepts electrons from NADPH in the cytosol to reduce oxygen to the superoxide radical in the vacuolar lumen. The superoxide is instrumental in killing ingested microorganisms. Patients suffering from chronic granulomatous disease (CGD), in which this system is failing, are abnormally susceptible to infectious diseases. Studying CGD patients' neutrophils has been enormously helpful in identifying the components of the superoxide-generating system, known as the NADPH oxidase. This review will describe the components of the electron-transport chain involved in the oxidase and the factors needed for its regulation.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Bacteria / immunology
  • Binding Sites
  • Cytochromes / metabolism
  • Cytosol / chemistry
  • Electron Transport / immunology*
  • Forecasting
  • GTP-Binding Proteins / metabolism
  • Gene Targeting
  • Humans
  • Membrane Glycoproteins / metabolism
  • Mutation
  • NADPH Oxidase 2
  • NADPH Oxidases / immunology*
  • Phagocytes / immunology
  • Phosphoproteins / chemistry
  • Phosphoproteins / metabolism
  • Phosphorylation
  • Proteins / metabolism
  • Respiratory Burst / immunology*
  • src Homology Domains

Substances

  • Cytochromes
  • Membrane Glycoproteins
  • Phosphoproteins
  • Proteins
  • neutrophil cytosol factor 40K
  • neutrophil cytosol factor 67K
  • CYBB protein, human
  • NADPH Oxidase 2
  • NADPH Oxidases
  • neutrophil cytosolic factor 1
  • GTP-Binding Proteins