The use of tissue plasminogen activator in post-traumatic total hyphaema

Graefes Arch Clin Exp Ophthalmol. 1996 Jan;234(1):67-8. doi: 10.1007/BF00186522.


Background: We wanted to evaluate whether intracameral injection of tissue plasminogen activator (tPA) is useful in managing traumatic hyphaema.

Methods: Two eyes with total hyphaema after a severe penetrating injury were treated with a single intracameral injection of 25 micrograms of tPA 5 and 14 days after the injury, respectively.

Results: Most of the blood coagulum dissolved within 24 h, and in one of the two eyes the intraocular pressure decreased from 45 to 8 mmHg. The other eye was hypotonic. No re-bleeding or complications related to the use of tPA were noticed.

Conclusion: The results in these two cases suggest that tPA is a useful adjunct in managing total hyphaema.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Anterior Chamber / drug effects
  • Eye Injuries, Penetrating / complications*
  • Humans
  • Hyphema / drug therapy*
  • Hyphema / etiology
  • Injections
  • Male
  • Middle Aged
  • Plasminogen Activators / therapeutic use*
  • Sclera / injuries*
  • Thrombolytic Therapy*
  • Tissue Plasminogen Activator / therapeutic use*


  • Plasminogen Activators
  • Tissue Plasminogen Activator