RU 24969-induced locomotion in rats is mediated by 5-HT1A receptors

Naunyn Schmiedebergs Arch Pharmacol. 1995 Nov;352(5):583-4. doi: 10.1007/BF00169395.

Abstract

The locomotor response to RU 24969 (5-methoxy-3-(1,2,3,6-tetrahydropyridin-4-yl) 1H-indole; 10 mg/kg, s.c.), a preferential 5-HT(1B) receptor agonist, was investigated in the rat, using two novel 5-HT(1A) receptor antagonists, WAY-100635 (0.3 mg/kg and 1 mg/kg, s.c.) and SDZ 216-525 (0.3 mg/kg, s.c.), and the novel 5-HT(1B)/5-HT(1D) receptor antagonist, GR 127935 (1 mg/kg, s.c.). The antagonists per se did not alter spontaneous locomotion. Both selective 5-HT(1A) receptor antagonists blocked RU 24969-induced hyperlocomotion, whilst the 5-HT(1B) receptor antagonist was without effect. These results suggest that RU 24969-induced hyperlocomotion in the rat is mediated by 5-HT(1A) receptors.

MeSH terms

  • Animals
  • Indoles / pharmacology*
  • Locomotion / drug effects*
  • Male
  • Piperazines / pharmacology
  • Pyridines / pharmacology
  • Rats
  • Rats, Wistar
  • Receptors, Serotonin / drug effects*
  • Receptors, Serotonin / physiology
  • Receptors, Serotonin, 5-HT1
  • Serotonin Antagonists / pharmacology*
  • Serotonin Receptor Agonists / pharmacology*
  • Thiazoles / pharmacology

Substances

  • Indoles
  • Piperazines
  • Pyridines
  • Receptors, Serotonin
  • Receptors, Serotonin, 5-HT1
  • Serotonin Antagonists
  • Serotonin Receptor Agonists
  • Thiazoles
  • SDZ 216-525
  • 5-methoxy 3-(1,2,3,6-tetrahydro-4-pyridinyl)1H indole
  • N-(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)-N-(2-pyridinyl)cyclohexanecarboxamide