Effects of omeprazole and lansoprazole on fasting and postprandial serum gastrin and serum pepsinogen A and C

Hepatogastroenterology. Sep-Oct 1995;42(5):677-82.

Abstract

Background/aims: The aim of this study was to examine effects of two H+/K(+)-ATPase antagonists (omeprazole and lansoprazole) on fasting and postprandial serum gastrin and serum pepsinogens A and C.

Materials and methods: In 8 healthy volunteers, either 20 mg of omeprazole or 30 mg of lansoprazole once daily for 7 days were administered in a double blind and randomized design. After a two-week period to "wash out" the drug, each treatment was then crossed over. Fasting and postprandial serum gastrin and serum pepsinogens A and C levels were measured at baseline and at the end of the treatment.

Results: Omeprazole increased fasting levels of serum gastrin and serum pepsinogen A and C. A similar finding was observed after lansoprazole administration. The test meal increased serum gastrin level but did not serum pepsinogens A and C either before or after omeprazole and lansoprazole administration. In addition, the integrated meal stimulated incremental serum gastrin were not modified after omeprazole and lansoprazole administration.

Conclusions: This data suggests that both omeprazole and lansoprazole increase fasting serum gastrin and serum pepsinogen A and C levels, but have no effects on postprandial serum gastrin and pepsinogens levels.

Publication types

  • Clinical Trial
  • Randomized Controlled Trial

MeSH terms

  • 2-Pyridinylmethylsulfinylbenzimidazoles
  • Adult
  • Cross-Over Studies
  • Double-Blind Method
  • Eating / drug effects
  • Eating / physiology*
  • Enzyme Inhibitors / administration & dosage*
  • Fasting / blood*
  • Female
  • Gastrins / blood*
  • Gastrins / drug effects
  • Humans
  • Lansoprazole
  • Male
  • Omeprazole / administration & dosage*
  • Omeprazole / analogs & derivatives*
  • Pepsinogens / blood*
  • Pepsinogens / drug effects

Substances

  • 2-Pyridinylmethylsulfinylbenzimidazoles
  • Enzyme Inhibitors
  • Gastrins
  • Pepsinogens
  • Lansoprazole
  • Omeprazole