Three dynamin-encoding genes are differentially expressed in developing rat brain

J Neurochem. 1996 Sep;67(3):927-31. doi: 10.1046/j.1471-4159.1996.67030927.x.


Dynamin proteins are members of a recently described family of GTPases involved in receptor-mediated processes. To date, three different dynamin-encoding genes have been identified in mammalian tissues. Dynamin I is expressed only in neurons, whereas dynamin II is ubiquitously expressed. A third isoform, dynamin III, was originally isolated from a rat testis cDNA library and shown to be testis-specific. However, here we report the cloning and characterization of dynamin III from brain and lung, demonstrating a more extended pattern of expression for this isoform. In addition, we have investigated the temporal pattern of expression of these three genes during brain development. We find that both dynamin I and dynamin III mRNA levels are up-regulated during embryogenesis, whereas dynamin II mRNA levels remain unchanged. From these results, we conclude that dynamin III is not a testis-specific isoform and, furthermore, that rat brain expresses three different dynamin-encoding genes that are differentially regulated during development. Therefore, this large isoform diversity of dynamin proteins in brain predicts a significant complexity in the understanding of dynamin-based processes in this tissue.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Alternative Splicing / physiology
  • Amino Acid Sequence
  • Animals
  • Brain / embryology*
  • Brain / physiology
  • Dynamin I
  • Dynamin III
  • Dynamins
  • Endocytosis / genetics
  • GTP Phosphohydrolases / chemistry
  • GTP Phosphohydrolases / genetics*
  • Gene Expression Regulation, Developmental / physiology
  • Gene Library
  • Genetic Testing
  • Isoenzymes / chemistry
  • Isoenzymes / genetics
  • Lung / physiology
  • Male
  • Microtubules / chemistry
  • Microtubules / genetics
  • Molecular Sequence Data
  • PC12 Cells / physiology
  • RNA, Messenger / analysis
  • Rats
  • Rats, Sprague-Dawley
  • Testis / physiology
  • Time Factors


  • Isoenzymes
  • RNA, Messenger
  • Dynamin I
  • GTP Phosphohydrolases
  • Dynamin III
  • Dynamins