Psoriasin: A Novel Chemotactic Protein

J Invest Dermatol. 1996 Jul;107(1):5-10. doi: 10.1111/1523-1747.ep12294284.

Abstract

Inflammatory skin disorders such as psoriasis show a preferential epidermal infiltration of neutrophils and T lymphocytes. This observation raises a question as to which factors determine the appearance and composition of leukocyte tissue infiltrations. Previously, we described a low molecular mass calcium-binding protein (psoriasin, molecular mass 11,457 Da, pI 6.77) belonging to the S1OO family that is highly upregulated in psoriatic keratinocytes and whose expression patterns implied a role in the inflammatory response. Here we report that human psoriasin is a potent and selective chemotactic inflammatory protein for CD4+ T lymphocytes and neutrophils at concentrations of about 10(-11) M. Psoriasin is not structurally related to the alpha or the beta chemokine subfamilies or to lymphotactin, a member of a newly described class of chemokines. Thus, we have observed a chemotactic protein outside the chemokine subfamilies that could be an important new inflammatory mediator.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • CD4-Positive T-Lymphocytes / physiology
  • Calcium-Binding Proteins / physiology*
  • Chemotactic Factors / physiology*
  • Chemotaxis, Leukocyte / drug effects
  • Collagen / pharmacology
  • Humans
  • Neutrophils / physiology
  • Recombinant Proteins
  • S100 Calcium Binding Protein A7
  • S100 Proteins
  • T-Lymphocytes / physiology

Substances

  • Calcium-Binding Proteins
  • Chemotactic Factors
  • Recombinant Proteins
  • S100 Calcium Binding Protein A7
  • S100 Proteins
  • S100A7 protein, human
  • Collagen