99mTc-MIBI scintigraphy in metastatic renal cell carcinoma: clinical validation of the relationship between 99mTc-MIBI uptake and P-glycoprotein expression in tumour tissue

Eur J Nucl Med. 1996 Aug;23(8):976-9. doi: 10.1007/BF01084374.

Abstract

Technetium-99m hexakis-2-methoxyisobutylisonitrile (MIBI) and thallium-201 imaging was performed in a patient with metastatic renal cell carcinoma (RCC), which is a well-known tumour type demonstrating P1-glycoprotein (PGP) overexpression. Two scintigraphic patterns - Tl(+)/MIBI(-) in primary tumour and Tl(+)/MIBI(+) in metastatic tumour - were observed, suggesting high- and low-level PGP expression, respectively. Immunochemical study for PGP revealed strong staining of the primary tumour cells. This case clinically validates the previously suggested relationship between 99mTc-MIBI uptake and PGP expression.

Publication types

  • Case Reports

MeSH terms

  • ATP Binding Cassette Transporter, Subfamily B, Member 1 / biosynthesis*
  • Aged
  • Carcinoma, Renal Cell / diagnostic imaging*
  • Carcinoma, Renal Cell / genetics
  • Carcinoma, Renal Cell / secondary*
  • Gene Expression Regulation, Neoplastic
  • Humans
  • Kidney Neoplasms / diagnostic imaging*
  • Kidney Neoplasms / genetics
  • Lung Neoplasms / diagnostic imaging*
  • Lung Neoplasms / genetics
  • Lung Neoplasms / secondary*
  • Male
  • Radionuclide Imaging
  • Technetium Tc 99m Sestamibi*
  • Thallium Radioisotopes

Substances

  • ATP Binding Cassette Transporter, Subfamily B, Member 1
  • Thallium Radioisotopes
  • Technetium Tc 99m Sestamibi