Free xenotransplantation of cryopreserved Langerhans cells (67 cases) and deportalization of pancreatic blood supply (37 patients) was done in 104 patients with insulin-dependent diabetes mellitus with positive effect. There were 58 men and 46 women at the age of 16-62 years. In 15 cases the combination of these two methods has been used that made it possible to enforce the antidiabetic effect and stabilize the development of diabetic complications.