[Criterion quality and estimation of the expected sample size in sequential analysis of linkage]

Genetika. 1996 May;32(5):709-15.
[Article in Russian]


It is shown that, when conducting sequential testing of linkage in pedigree samples, (1) type I and type II errors observed are less than expected and (2) the generally accepted method for determining the average sample size, E(N), required for sequential analysis of linkage, underestimates it. A less biased approximation of E(N) is proposed. A wide scattering of actual sample sizes required for completion of sequential analysis is demonstrated, which puts practical use of E(N) into question.

Publication types

  • English Abstract

MeSH terms

  • Evaluation Studies as Topic
  • Genetic Linkage*
  • Humans
  • Linear Models
  • Models, Genetic
  • Models, Statistical
  • Pedigree
  • Reproducibility of Results
  • Sample Size
  • Sequence Analysis, DNA / methods*