Abstract
A new case of thymoma, myasthenia gravis and pure red cell aplasia is presented. Pure red cell aplasia came out 10 years after the diagnosis of the two other diseases in one of several relapses of metastatic thymoma with clinical signs of myasthenia. Surgery, chemotherapy and radiotherapy besides pyridostigmine treatment were used in the clinical course of the patient. A phenotypical change of medullary T lymphocytes (CD4 to CD8) was observed at the same time of pure red cell aplasia diagnosis. A dual role of medullary CD2+ T cell lymphocytes, stimulant and suppressive, over erythroid progenitor cells (BFU-E and CFU-E) was suggested by in vitro cultures.
Publication types
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Case Reports
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English Abstract
MeSH terms
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Aged
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Antigens, CD / analysis
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Autoimmune Diseases / drug therapy
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Autoimmune Diseases / etiology*
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Autoimmune Diseases / surgery
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Cells, Cultured
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Cholinesterase Inhibitors / therapeutic use
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Combined Modality Therapy
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Erythroid Precursor Cells / pathology
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Female
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Humans
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Immunophenotyping
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Myasthenia Gravis / drug therapy
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Myasthenia Gravis / etiology*
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Myasthenia Gravis / surgery
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Neoplasm Recurrence, Local
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Pyridostigmine Bromide / therapeutic use
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Red-Cell Aplasia, Pure / complications*
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Red-Cell Aplasia, Pure / drug therapy
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T-Lymphocyte Subsets / immunology*
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Thymoma / complications*
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Thymoma / pathology
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Thymoma / radiotherapy
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Thymoma / secondary
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Thymoma / surgery
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Thymus Neoplasms / complications*
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Thymus Neoplasms / pathology
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Thymus Neoplasms / radiotherapy
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Thymus Neoplasms / surgery
Substances
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Antigens, CD
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Cholinesterase Inhibitors
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Pyridostigmine Bromide