Asymmetric localization of a mammalian numb homolog during mouse cortical neurogenesis

Neuron. 1996 Jul;17(1):43-53. doi: 10.1016/s0896-6273(00)80279-2.


During Drosophila neurogenesis, differential segregation of Numb is necessary for daughter cells of asymmetric divisions to adopt distinct fates, at least partly by biasing the Notch-mediated cell-cell interaction. We have isolated a highly conserved mammalian homolog of Drosophila numb, m-numb. During mouse cortical neurogenesis, m-Numb is asymmetrically localized to the apical membrane of dividing ventricular neural progenitors. Depending upon the orientation of the cleavage plane, m-Numb may be distributed into one or both of the daughter cells. When expressed in Drosophila embryos, m-Numb is localized asymmetrically in dividing neural precursors and rescues the numb mutant phenotype. Furthermore, m-Numb can physically interact with mouse Notch1. We propose that some shared molecular mechanisms, both cell-intrinsic and cell-extrinsic, generate asymmetric cell divisions during neurogenesis of vertebrates and invertebrates.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Cell Division
  • Cell Membrane / metabolism
  • Cerebral Cortex / cytology
  • Cerebral Cortex / embryology*
  • Cerebral Cortex / metabolism*
  • Drosophila
  • Drosophila Proteins
  • Embryo, Mammalian / metabolism
  • Embryo, Nonmammalian
  • Embryonic and Fetal Development*
  • Juvenile Hormones / genetics
  • Juvenile Hormones / metabolism*
  • Membrane Proteins / metabolism
  • Mice / embryology*
  • Molecular Sequence Data
  • Mutation
  • Neurons / metabolism
  • Rats
  • Receptors, Cell Surface / metabolism
  • Receptors, Notch
  • Sequence Homology, Amino Acid
  • Tissue Distribution


  • Drosophila Proteins
  • Juvenile Hormones
  • Membrane Proteins
  • N protein, Drosophila
  • Receptors, Cell Surface
  • Receptors, Notch
  • numb protein, Drosophila

Associated data

  • GENBANK/U70674