Objective: To investigate the role of amino acid played in pathogenesis of small for gestational age (SGA) fetuses.
Methods: Plasma amino acids' concentrations (PAAC) of umbilical venous samples obtained by cordocentesis before labor or at cesarean section were measured in 30 cases of appropriate for gestational age (AGA) fetuses at different gestational age. PAAC of both mother and fetuses were measured and compared in 10 cases of SGA and 10 cases of AGA.
Results: In cases of AGA, the PAAC in fetuses (3.11 +/- 0.41 mmol/L) were found to be higher than that in mothers. There were significant correlations between fetal and maternal PAAC. The total PAAC in mothers and fetuses, and its ratios were not changed with gestational age. In cases of SGA, essential amino acids' concentration (EAA), especially branch chain amino acid (BCAA) and lysine, decreased significantly. The feto-maternal ratios of EAA and BCAA were reduced significantly, whereas concentrations of EAA and BCAA in mothers did not change significantly.
Conclusions: The results indicated that placental function and maternal nutrient supplement were important factors for maintaining fetal growth and development. In AGA cases, relationship of PAAC between mothers and fetuses were kept in a stable balance. In SGA fetuses certain amino acid metabolic disturbances existed. The reduction of some PAAC was not due to their decrease in mothers.