Abstract
Ehretianone (1), a new quinonoid xanthene, together with known sterols, was isolated from a MeOH extract of the root bark of Ehretia buxifolia. The structure of ehretianone was elucidated as 7-hydroxy-9a alpha-(3-methylbut-2-enyl)-4a alpha,9 alpha-(2-methylprop-2-enyl)-4a, 9a-dihydro-1,4-dioxoxanthene on the basis of spectroscopic data and X-ray crystallographic analysis. The antisnake venom activity of ehretianone against Echis carinatus venom in mice is also reported.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Lethal Dose 50
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Magnetic Resonance Spectroscopy
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Mice
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Plant Extracts / chemistry
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Plant Extracts / pharmacology
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Plant Roots / chemistry
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Plants, Medicinal / chemistry*
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Quinones / chemistry
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Quinones / isolation & purification
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Quinones / pharmacology*
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Snake Venoms / antagonists & inhibitors*
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Spectrophotometry, Infrared
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Viper Venoms / antagonists & inhibitors
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Viper Venoms / toxicity
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Xanthenes / chemistry
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Xanthenes / isolation & purification
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Xanthenes / pharmacology*
Substances
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Plant Extracts
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Quinones
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Snake Venoms
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Viper Venoms
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Xanthenes
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ehretianone