Ehretianone, a novel quinonoid xanthene from Ehretia buxifolia with antisnake venom activity

J Nat Prod. 1996 Jul;59(7):664-7. doi: 10.1021/np960355p.

Abstract

Ehretianone (1), a new quinonoid xanthene, together with known sterols, was isolated from a MeOH extract of the root bark of Ehretia buxifolia. The structure of ehretianone was elucidated as 7-hydroxy-9a alpha-(3-methylbut-2-enyl)-4a alpha,9 alpha-(2-methylprop-2-enyl)-4a, 9a-dihydro-1,4-dioxoxanthene on the basis of spectroscopic data and X-ray crystallographic analysis. The antisnake venom activity of ehretianone against Echis carinatus venom in mice is also reported.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Lethal Dose 50
  • Magnetic Resonance Spectroscopy
  • Mice
  • Plant Extracts / chemistry
  • Plant Extracts / pharmacology
  • Plant Roots / chemistry
  • Plants, Medicinal / chemistry*
  • Quinones / chemistry
  • Quinones / isolation & purification
  • Quinones / pharmacology*
  • Snake Venoms / antagonists & inhibitors*
  • Spectrophotometry, Infrared
  • Viper Venoms / antagonists & inhibitors
  • Viper Venoms / toxicity
  • Xanthenes / chemistry
  • Xanthenes / isolation & purification
  • Xanthenes / pharmacology*

Substances

  • Plant Extracts
  • Quinones
  • Snake Venoms
  • Viper Venoms
  • Xanthenes
  • ehretianone