Evidence for two distinct tumor-suppressor gene loci on the long arm of chromosome 11 in human oral cancer

Int J Cancer. 1996 Aug 7;67(4):510-4. doi: 10.1002/(SICI)1097-0215(19960807)67:4<510::AID-IJC8>3.0.CO;2-V.


Loss of heterozygosity (LOH) on human chromosome 11 has been reported in a variety of human cancers. To search for the existence of tumor-suppressor gene(s) associated with oral squamous cell carcinoma (SCC) on chromosome 11, we have performed high-resolution deletion mapping in 31 patients with oral SCC using 22 microsatellite markers for this chromosomal region. LOH was observed in 14 of 25 cases (56.0%) that were informative with at least one locus. Most allelic deletions detected in our study were specific to the long arm of the chromosome. Furthermore, the data presented here show 2 distinct, commonly deleted regions. The first region, with frequent LOH, was restricted between markers DIIS939 and DIIS924 separated by 3 centimorgans (cM) on chromosome 11q23. The second region of common deletion was identified between markers DIIS912 and DIIS910, separated by 7 cM at 11q25. Our results suggest that at least 2 tumor-suppressor genes involved in the development of oral SCC are present on the long arm of chromosome 11.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Carcinoma, Squamous Cell / genetics*
  • Carcinoma, Squamous Cell / pathology
  • Chromosome Deletion*
  • Chromosome Mapping
  • Chromosomes, Human, Pair 11*
  • DNA, Satellite
  • Gene Deletion
  • Genes, Tumor Suppressor*
  • Genetic Markers
  • Humans
  • Lymphatic Metastasis
  • Mouth Neoplasms / genetics*
  • Mouth Neoplasms / pathology
  • Neoplasm Staging
  • Polymerase Chain Reaction


  • DNA, Satellite
  • Genetic Markers