Angiotensin-converting enzyme and heart chymase gene polymorphisms in hypertrophic cardiomyopathy

Am J Cardiol. 1996 Aug 1;78(3):362-4. doi: 10.1016/s0002-9149(96)00296-2.


We examined the insertion/deletion polymorphism in the angiotensin-converting enzyme gene and identified polymorphisms in the heart chymase gene to test the hypothesis that these angiotensin II-producing enzymes are associated with a monogenic cardiac disease (50 patients and 50 control subjects) as a model of cardiac hypertrophy. We found that the angiotensin-converting enzyme DD genotype was present more often in patients than in control subjects and identified a possible interaction with 1 of the chymase polymorphisms.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Alleles
  • Base Sequence
  • Cardiomyopathy, Hypertrophic / enzymology
  • Cardiomyopathy, Hypertrophic / genetics*
  • Chymases
  • Female
  • Genotype
  • Humans
  • Male
  • Middle Aged
  • Molecular Sequence Data
  • Myocardium / enzymology*
  • Peptidyl-Dipeptidase A / genetics*
  • Polymerase Chain Reaction / methods
  • Polymorphism, Restriction Fragment Length*
  • Serine Endopeptidases / genetics*


  • Peptidyl-Dipeptidase A
  • Serine Endopeptidases
  • Chymases