A plasmocyte selective monoclonal antibody (B-B4) recognizes syndecan-1

Br J Haematol. 1996 Aug;94(2):318-23. doi: 10.1046/j.1365-2141.1996.d01-1811.x.


We developed a new monoclonal antibody. B-B4, which specifically identifies human plasma cells. It strongly reacts with all multiple myeloma cell lines and with malignant plasma cells of all tumour samples of the multiple myeloma patients tested. B-B4 does not react with any peripheral blood, bone marrow or tonsil cells. Cloning of the B-B4 antigen reveals that the monoclonal antibody recognizes syndecan-1. It appears that the monoclonal antibody B-B4 is a suitable marker for human plasmocyte identification among haemopoietic cells and a useful probe for the diagnosis of haematological malignancies. Furthermore, this monoclonal antibody can be used for depletions prior to CD34 grafting.

MeSH terms

  • Antibodies, Monoclonal / immunology*
  • Biomarkers, Tumor
  • Blood Cells / immunology
  • Blotting, Western
  • Bone Marrow / immunology
  • Cloning, Molecular
  • Electrophoresis, Agar Gel
  • Humans
  • Membrane Glycoproteins / immunology*
  • Multiple Myeloma / diagnosis*
  • Multiple Myeloma / immunology
  • Palatine Tonsil / immunology
  • Plasma Cells
  • Proteoglycans / immunology*
  • Syndecan-1
  • Syndecans
  • Tumor Cells, Cultured


  • Antibodies, Monoclonal
  • Biomarkers, Tumor
  • Membrane Glycoproteins
  • Proteoglycans
  • SDC1 protein, human
  • Syndecan-1
  • Syndecans