Equine rhinovirus serotypes 1 and 2: relationship to each other and to aphthoviruses and cardioviruses

J Gen Virol. 1996 Aug;77 ( Pt 8):1719-30. doi: 10.1099/0022-1317-77-8-1719.

Abstract

Equine rhinoviruses (ERVs) are picornaviruses which cause a mild respiratory infection in horses. The illness resembles the common cold brought about by rhinoviruses in humans; however, the presence of a viraemia during ERV-1 infection, the occurrence of persistent infections and the physical properties are all more reminiscent of foot-and-mouth disease virus (FMDV). cDNA cloning and sequencing of the genomes of ERV-1 and ERV-2 between the poly(C) and poly(A) tracts showed that the serotypes are heterogeneous. Nevertheless, the genomic architecture of both serotypes is most similar to that of FMDV. Indeed, a comparison of the derived protein sequences of ERV-1 shows that their identity is greatest to FMDV. In contrast, most ERV-2 proteins are more related to encephalomyocarditis virus (EMCV) proteins than they are to FMDV or ERV-1. These results place ERV-1 alongside FMDV in the aphthovirus genus of the picornavirus family and indicate that this virus may serve as a model system for examining the biology of FMDV.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Aphthovirus / classification
  • Aphthovirus / genetics
  • Base Sequence
  • Capsid / chemistry
  • Cardiovirus / classification
  • Cardiovirus / genetics
  • Cell Line
  • DNA, Viral
  • Genome, Viral
  • Humans
  • Introns
  • Molecular Sequence Data
  • Picornaviridae / classification*
  • Picornaviridae / genetics
  • Rabbits
  • Sequence Homology, Amino Acid
  • Serotyping
  • Viral Proteins / genetics

Substances

  • DNA, Viral
  • Viral Proteins

Associated data

  • GENBANK/X96870
  • GENBANK/X96871