Reduction of interstitial fluid pressure after TNF-alpha treatment of three human melanoma xenografts

Br J Cancer. 1996 Aug;74(4):533-6. doi: 10.1038/bjc.1996.397.

Abstract

Tumour necrosis factor-alpha (TNF-alpha) reduced the interstitial fluid pressure (IFP) to 54-64% (P < 0.05) and the mean arterial blood pressure (MABP) to 70% (P < 0.01) of control values after 5 h in three human melanoma tumour lines transplanted to nude mice.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Analysis of Variance
  • Animals
  • Bicarbonates / blood
  • Blood Pressure / drug effects
  • Carbon Dioxide / blood
  • Cell Line
  • Extracellular Space / drug effects
  • Extracellular Space / physiology*
  • Humans
  • Hydrogen-Ion Concentration
  • Male
  • Melanoma / blood
  • Melanoma / physiopathology*
  • Melanoma / therapy*
  • Mice
  • Mice, Nude
  • Oxygen / blood
  • Partial Pressure
  • Pressure
  • Respiration / drug effects
  • Time Factors
  • Transplantation, Heterologous
  • Tumor Necrosis Factor-alpha / therapeutic use*

Substances

  • Bicarbonates
  • Tumor Necrosis Factor-alpha
  • Carbon Dioxide
  • Oxygen