The GABAB receptor antagonist CGP 36,742 and the nootropic oxiracetam facilitate the formation of long-term memory

Behav Brain Res. 1996 May;77(1-2):223-5. doi: 10.1016/0166-4328(95)00222-7.

Abstract

The memory-enhancing effects of a single treatment with the GABAB antagonist CGP 36,742 (10 mg/kg) or the nootropic agent oxiracetam (100 mg/kg) given immediately after a learning experience ('post-trial') remain detectable for at least 4 months thereafter. This indicates that in all probability these substances facilitate the formation of the long-term memory trace.

MeSH terms

  • Animals
  • Brain / drug effects
  • Dose-Response Relationship, Drug
  • Female
  • GABA Antagonists / pharmacology*
  • Long-Term Potentiation / drug effects*
  • Mental Recall / drug effects*
  • Mice
  • Mice, Inbred Strains
  • Nootropic Agents / pharmacology*
  • Organophosphorus Compounds / pharmacology*
  • Pyrrolidines / pharmacology*
  • Receptors, GABA-B / drug effects*

Substances

  • GABA Antagonists
  • Nootropic Agents
  • Organophosphorus Compounds
  • Pyrrolidines
  • Receptors, GABA-B
  • (3-aminopropyl)(n-butyl)phosphinic acid
  • oxiracetam