Immunoglobulins of camel (Camelus dromedarius) colostrum

J Comp Pathol. 1996 Apr;114(3):273-82. doi: 10.1016/s0021-9975(96)80049-1.

Abstract

Immunoglobulins G, M and A were identified in dromedary camel colostra by acid precipitation, gel filtration and fast-protein liquid chromatography (ion exchange). Heavy and light chains were identified by polyacrylamide gel electrophoresis and Western blotting. IgG subclasses (IgG1, IgG2 and IgG3) were isolated by DEAE ion-exchange chromatography and shown to have different electrophoretic mobilities. Cross-reactivity of camel IgA with IgA of other species was determined by enzyme-linked immunosorbent assay (ELISA). Most of the immunoglobulin content was IgG, but a molecule identifiable as IgA was detected and purified. It would appear that in the camel, as in cattle, IgG is the major secretory immunoglobulin of colostrum.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Camelus / immunology*
  • Cats
  • Chromatography / methods
  • Colostrum / immunology*
  • Cross Reactions
  • Female
  • Horses / immunology
  • Humans
  • Immunoglobulin A / immunology
  • Immunoglobulin A / isolation & purification
  • Immunoglobulins / analysis*
  • Immunoglobulins / classification
  • Immunoglobulins / immunology
  • Immunoglobulins / isolation & purification
  • Mice
  • Species Specificity
  • Swine / immunology

Substances

  • Immunoglobulin A
  • Immunoglobulins