Inherited muscular disorder in mutant Japanese quail (Coturnix coturnix japonica): an ultrastructural study

J Comp Pathol. 1996 Apr;114(3):325-37. doi: 10.1016/s0021-9975(96)80054-5.


Ultrastructural study of muscles taken from a mutant (LWC) strain of Japanese quail with myotonia showed type 2 fibre atrophy, ring fibre formation, sarcoplasmic masses, and "moth-eaten" fibres. In these abnormal fibres, the most characteristic feature was the loss of interconnection among the myofibrils, mitochondria, and T tubules. Apparently normal muscle fibres often showed mild changes, such as proliferation of T tubules and enlarged sarcoplasmic areas with increased glycogen granules and ribosomes at the periphery of the fibres. The study suggested that one possible cause of these ultrastructural changes was a defect in cytoskeleton of muscle cells, especially in intermediate filaments.

Publication types

  • Comparative Study

MeSH terms

  • Animals
  • Atrophy
  • Coturnix / genetics*
  • Disease Models, Animal*
  • Female
  • Humans
  • Intermediate Filaments / ultrastructure
  • Male
  • Muscle Fibers, Skeletal / ultrastructure*
  • Muscular Dystrophy, Animal / pathology
  • Myotonic Dystrophy / genetics
  • Myotonic Dystrophy / pathology
  • Myotonic Dystrophy / veterinary*
  • Poultry Diseases / genetics
  • Poultry Diseases / pathology*
  • Sarcoplasmic Reticulum / ultrastructure
  • Species Specificity