Neutralizing antibodies to different proteins of African swine fever virus inhibit both virus attachment and internalization

J Virol. 1996 Aug;70(8):5689-94. doi: 10.1128/JVI.70.8.5689-5694.1996.


African swine fever virus induces in convalescent pigs antibodies that neutralized the virus before and after binding to susceptible cells, inhibiting both virus attachment and internalization. A further analysis of the neutralization mechanisms mediated by the different viral proteins showed that antibodies to proteins p72 and p54 are involved in the inhibition of a first step of the replication cycle related to virus attachment, while antibodies to protein p30 are implicated in the inhibition of virus internalization.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • African Swine Fever / virology*
  • African Swine Fever Virus / immunology*
  • African Swine Fever Virus / metabolism
  • Animals
  • Antibodies, Viral / immunology*
  • Antibodies, Viral / pharmacology
  • Swine
  • Viral Proteins / immunology*
  • Virus Replication / drug effects
  • Virus Replication / immunology*


  • Antibodies, Viral
  • Viral Proteins