Treatment of urinary-tract infection with a single dose of amoxycillin

Nephron. 1977;18(6):316-20. doi: 10.1159/000180849.

Abstract

31 patients with a urinary infection were treated with a single oral dose (3 g for adults and 100 mg/kg for children) of amoxycillin; 23 (74%) were cured. 20 women and 26 children were then randomly allocated to either a single dose of amoxycillin of a 5- to 7-day conventional course of the same antibiotic. The results of both treatment regimens were comparable. Single-dose therapy for the treatment of urinary-tract infections was simple, effective and well tolerated. Patients preferred taking their treatment in this manner. Failure of single-dose therapy to eradicate bacteriuria may indicate which patients require subsequent investigations of their urinary tract.

Publication types

  • Clinical Trial
  • Comparative Study
  • Randomized Controlled Trial

MeSH terms

  • Administration, Oral
  • Adolescent
  • Adult
  • Aged
  • Amoxicillin / administration & dosage*
  • Amoxicillin / blood
  • Amoxicillin / urine
  • Ampicillin / analogs & derivatives*
  • Child
  • Child, Preschool
  • Female
  • Humans
  • Infant
  • Male
  • Middle Aged
  • Urinary Tract Infections / drug therapy*

Substances

  • Ampicillin
  • Amoxicillin