Valinomycin acts as a channel in ultrathin lipid membranes

Biochim Biophys Acta. 1996 Aug 14;1283(1):1-3. doi: 10.1016/0005-2736(96)00101-0.


When the thickness of monolayer membranes formed by bolaform archaeal lipids is reduced to the approximate length of two valinomycin molecules, the zero-current conductance does not show any more a linear dependence on valinomycin concentration; instead, a quadratic behaviour is observed. This suggests that a dimer permeation pore is formed and therefore the conduction mechanism changes from carrier to channel.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alkanes
  • Chloroform
  • Diglycerides / chemistry
  • Diglycerides / metabolism
  • Electric Conductivity
  • Ion Channels*
  • Lipid Bilayers / metabolism
  • Membranes, Artificial*
  • Valinomycin / metabolism*


  • Alkanes
  • Diglycerides
  • Ion Channels
  • Lipid Bilayers
  • Membranes, Artificial
  • glycerol dialkyl nonitol tetraethyl ether
  • Valinomycin
  • Chloroform
  • decane