Direct enzymatic assay of urinary sulfated bile acids to replace serum bilirubin testing for selective screening of neonatal cholestasis

A Matsui; Y Kasano; Y Yamauchi; T Momoya; T Shimada; T Ishikawa; D Abukawa; A Kimura; K Adachi; Y Tazuke

doi:10.1016/s0022-3476(96)70260-3

Direct enzymatic assay of urinary sulfated bile acids to replace serum bilirubin testing for selective screening of neonatal cholestasis

J Pediatr. 1996 Aug;129(2):306-8. doi: 10.1016/s0022-3476(96)70260-3.

Authors

A Matsui¹, Y Kasano, Y Yamauchi, T Momoya, T Shimada, T Ishikawa, D Abukawa, A Kimura, K Adachi, Y Tazuke

Affiliation

¹ Department of Pediatrics, Jichi Medical School, Tochigi, Japan.

PMID: 8765633
DOI: 10.1016/s0022-3476(96)70260-3

Abstract

Direct enzymatic assay of urinary sulfated bile acids is a sensitive, rapid, minimally invasive, and convenient method of detecting cholestasis in young infants. It may replace measurement of serum direct bilirubin for selective screening for biliary atresia and neonatal hepatitis syndrome at 1 month of age.

MeSH terms

Bile Acids and Salts / urine*
Biliary Atresia / blood
Biliary Atresia / diagnosis
Biliary Atresia / urine
Bilirubin / blood*
Cholestasis / blood
Cholestasis / diagnosis*
Cholestasis / urine
Female
Hepatitis / blood
Hepatitis / diagnosis
Hepatitis / urine
Humans
Infant
Infant, Newborn
Male
Neonatal Screening*
Sensitivity and Specificity
Sulfates / urine
Syndrome

Substances

Bile Acids and Salts
Sulfates
Bilirubin