Molecular cloning of the cDNA encoding a helix-loop-helix protein, mouse ID1B: tissue-specific expression of ID1A and ID1B genes

Biochim Biophys Acta. 1996 Jul 31;1308(1):28-30. doi: 10.1016/0167-4781(96)00092-9.


A cDNA encoding a 168 amino acid mouse ID1B helix-loop-helix protein, the longest among the ID family of proteins so far identified, was cloned and its nucleotide sequence determined. Mouse ID1B mRNA is distinguishable from the mRNA encoding ID1A at its 3' end, and the relative level of expression of these two different mRNAs is similar in most tissues, with exception of skeletal muscle and kidney. Comparison of the most carboxyl terminal predicted amino acid sequences of ID1 proteins reveals 100% identity for ID1A, but the predicted Id1B proteins of several species are different.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Alternative Splicing
  • Amino Acid Sequence
  • Animals
  • Base Sequence
  • DNA, Complementary / genetics
  • Genetic Variation
  • Helix-Loop-Helix Motifs*
  • Inhibitor of Differentiation Protein 1
  • Mice
  • Molecular Sequence Data
  • Multigene Family*
  • Repressor Proteins*
  • Sequence Homology, Amino Acid
  • Species Specificity
  • Tissue Distribution
  • Transcription Factors / genetics*


  • DNA, Complementary
  • Idb1 protein, mouse
  • Inhibitor of Differentiation Protein 1
  • Repressor Proteins
  • Transcription Factors

Associated data

  • GENBANK/U43884