[Toxic retinopathy caused by intravitreal injection of amikacin and vancomycin]

Klin Monbl Augenheilkd. 1996 May;208(5):358-9. doi: 10.1055/s-2008-1035237.
[Article in French]

Abstract

Case report: Referred because of a right corneal perforation with cellular reaction in anterior chamber, a patient was sutured and treated with a single intravitreal injection of 0.2 ml (1 mg) Amikacin and 0.2 ml (1 mg) Vancomycin. Whereas the retina was normal before the injection, a diffuse retinal edema with intra- and preretinal hemorrhages was noted 12 hours postoperatively. Visual acuity was markedly reduced. ERG and visual field was also abnormal.

Conclusion: This case demonstrates that a single intravitreal injection of Amikacin and Vancomycin at usual concentration may induce retinal toxicity with permanent damage.

Publication types

  • Case Reports
  • English Abstract

MeSH terms

  • Amikacin / administration & dosage
  • Amikacin / adverse effects*
  • Anti-Bacterial Agents / administration & dosage
  • Anti-Bacterial Agents / adverse effects*
  • Corneal Injuries*
  • Drug Therapy, Combination / adverse effects
  • Drug Therapy, Combination / therapeutic use
  • Eye Injuries, Penetrating / drug therapy*
  • Humans
  • Injections
  • Male
  • Middle Aged
  • Retinal Diseases / chemically induced*
  • Vancomycin / administration & dosage
  • Vancomycin / adverse effects*
  • Vitreous Body / drug effects

Substances

  • Anti-Bacterial Agents
  • Vancomycin
  • Amikacin