Beta-endorphins ACTH and cortisol in CSF and plasma of HIV infected patients

Riv Eur Sci Med Farmacol. 1995 Sep-Oct;17(5):161-5.


Interactions between HPA (Hypothalamic-pituitary-axis) and immune system seem to involve the EPO (endogenous opioid peptides) system, as shown by some recent findings. Possible relationships between beta-endorphin (beta-End) synthesis and severity rate of immunodeficiency have been studied in 48 HIV Ab positive patients, at different stages of infection. A statistically significant decrease in the beta-End synthesis was observed in these patients, as compared to a control group of 19 healthy subjects, but this decrease was not related to the CD4+T lymphocytes number. Plasmatic levels modifications of HPA-related peptides were not observed in the IVC1 CDC group.

Publication types

  • Clinical Trial

MeSH terms

  • Acquired Immunodeficiency Syndrome / blood
  • Acquired Immunodeficiency Syndrome / cerebrospinal fluid
  • Acquired Immunodeficiency Syndrome / metabolism
  • Adrenocorticotropic Hormone / blood
  • Adrenocorticotropic Hormone / cerebrospinal fluid
  • Adrenocorticotropic Hormone / metabolism*
  • Adult
  • HIV Infections / blood
  • HIV Infections / cerebrospinal fluid
  • HIV Infections / metabolism*
  • Humans
  • Hydrocortisone / blood
  • Hydrocortisone / cerebrospinal fluid
  • Hydrocortisone / metabolism*
  • Middle Aged
  • beta-Endorphin / blood
  • beta-Endorphin / cerebrospinal fluid
  • beta-Endorphin / metabolism*


  • beta-Endorphin
  • Adrenocorticotropic Hormone
  • Hydrocortisone