Proteasome: from structure to function

Curr Opin Biotechnol. 1996 Aug;7(4):376-85. doi: 10.1016/s0958-1669(96)80111-x.


During the past two years, significant progress has been made in understanding the structure and function of the proteasome. Recent work has revealed the three-dimensional structure of the 700 kDa proteolytic complex at atomic resolution and elucidated its novel catalytic mechanism. Close relationships to a number of other amino-terminal hydrolases have emerged, making the proteasomal subunits the prototype of this newly discovered structural superfamily.

Publication types

  • Review

MeSH terms

  • Animals
  • Cysteine Endopeptidases / chemistry*
  • Cysteine Endopeptidases / immunology
  • Cysteine Endopeptidases / physiology*
  • Humans
  • Models, Biological
  • Models, Immunological
  • Models, Molecular
  • Multienzyme Complexes / chemistry*
  • Multienzyme Complexes / immunology
  • Multienzyme Complexes / physiology*
  • Proteasome Endopeptidase Complex
  • Protein Conformation
  • Protein Folding


  • Multienzyme Complexes
  • Cysteine Endopeptidases
  • Proteasome Endopeptidase Complex