Impaired IgG-dependent anaphylaxis and Arthus reaction in Fc gamma RIII (CD16) deficient mice

Immunity. 1996 Aug;5(2):181-8. doi: 10.1016/s1074-7613(00)80494-x.


The family of receptors for IgG (Fc gamma R) plays an essential role in antibody-mediated effector functions of the immune system. However, the specific contribution of each of the Fc gamma R classes to in vivo immune reactions is still unclear. Here, we demonstrate that mice deficient for the ligand-binding alpha chain of Fc gamma RIII lack NK cell-mediated antibody-dependent cytotoxicity and phagocytosis of IgG1-coated particles by macrophages. Strikingly, these mice lack IgG-mediated mast cell degranulation, are resistant to IgG-dependent passive cutaneous anaphylaxis, and exhibit an impaired Arthus reaction. These results indicate a prominent role for Fc gamma RIII in inflammatory and anaphylactic responses, making this receptor a potential target in immunotherapy.

MeSH terms

  • Animals
  • Antibody-Dependent Cell Cytotoxicity
  • Arthus Reaction / immunology*
  • Cell Degranulation / immunology
  • Erythrocytes / immunology
  • Female
  • Immunoglobulin G / blood
  • Immunoglobulin G / physiology*
  • Killer Cells, Natural / immunology
  • Male
  • Mast Cells / immunology
  • Mice
  • Mice, Inbred C57BL
  • Mice, Mutant Strains
  • Passive Cutaneous Anaphylaxis / immunology*
  • Phagocytosis / immunology
  • Receptors, IgG / deficiency*
  • Receptors, IgG / genetics*
  • Sheep / immunology


  • Immunoglobulin G
  • Receptors, IgG