Environmental and genetic risk factors in Parkinson's disease: a case-control study in southern Italy

Mov Disord. 1996 Jan;11(1):17-23. doi: 10.1002/mds.870110105.


To clarify the role of heredity and of some environment risk factors in the etiology of idiopathic Parkinson's disease, we performed a case-control study in two regions of southern Italy, Campania and Molise. We selected two controls for each parkinsonian patient, the patient's spouse and a sex- and age-matched neurological control. One hundred sixteen consecutive outpatients with Parkinson's disease (77 men, 39 women; mean age +/- SD = 62.5 +/- 9.9) and the same number of spouses and neurological controls were interviewed about five environmental risk factors (cigarette smoking, well-water drinking, head trauma with loss of consciousness, strict diets, general anesthesia) and two genetic risk factors (family history of Parkinson's disease or of essential tremor). Well-water drinking and family history of Parkinson's disease or essential tremor showed a positive association with Parkinson's disease; smoking showed a negative association. The most relevant risk factor was history of familial Parkinson's disease (odds ratio = 14.6; 95% confidence interval = 7.2 - 29.6); 33% of our patients had at least one affected relative. We also showed a unilateral distribution of ancestral secondary cases on the paternal or on the maternal side, which suggests a dominant inheritance. Clinical and epidemiologic features of cases with familial Parkinson's disease showed no peculiarity. The study suggests a strong role of the genetic factors in the etiology of Parkinson's disease.

MeSH terms

  • Aged
  • Case-Control Studies
  • Environmental Exposure / adverse effects*
  • Female
  • Humans
  • Italy
  • Male
  • Middle Aged
  • Neurologic Examination / drug effects
  • Odds Ratio
  • Parkinson Disease / etiology
  • Parkinson Disease / genetics*
  • Risk Factors
  • Smoking / adverse effects
  • Water Pollutants / adverse effects


  • Water Pollutants