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Review
, 21 (8), 296-301

The SR Protein Family: Pleiotropic Functions in pre-mRNA Splicing

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  • PMID: 8772383
Review

The SR Protein Family: Pleiotropic Functions in pre-mRNA Splicing

J Valcárcel et al. Trends Biochem Sci.

Abstract

A family of proteins with arginine-serine-rich domains has recently come into the limelight of studies on the mechanisms of constitutive and regulated pre-mRNA splicing. Implicated in an ever increasing variety of functions, these proteins act as driving forces during spliceosome assembly and also play decisive roles in alternative splice-site selection, suggesting that they are crucial players in the regulation of splicing during cell differentiation and development.

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