The SR protein family: pleiotropic functions in pre-mRNA splicing

Trends Biochem Sci. 1996 Aug;21(8):296-301.


A family of proteins with arginine-serine-rich domains has recently come into the limelight of studies on the mechanisms of constitutive and regulated pre-mRNA splicing. Implicated in an ever increasing variety of functions, these proteins act as driving forces during spliceosome assembly and also play decisive roles in alternative splice-site selection, suggesting that they are crucial players in the regulation of splicing during cell differentiation and development.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Arginine
  • Binding Sites
  • Enhancer Elements, Genetic
  • Humans
  • Models, Genetic
  • Phosphorylation
  • RNA Precursors / genetics*
  • RNA Splicing*
  • RNA, Messenger / genetics*
  • RNA, Messenger / metabolism
  • RNA-Binding Proteins / genetics*
  • RNA-Binding Proteins / physiology
  • Serine
  • Spliceosomes / metabolism


  • RNA Precursors
  • RNA, Messenger
  • RNA-Binding Proteins
  • Serine
  • Arginine