Abstract
A family of proteins with arginine-serine-rich domains has recently come into the limelight of studies on the mechanisms of constitutive and regulated pre-mRNA splicing. Implicated in an ever increasing variety of functions, these proteins act as driving forces during spliceosome assembly and also play decisive roles in alternative splice-site selection, suggesting that they are crucial players in the regulation of splicing during cell differentiation and development.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
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Review
MeSH terms
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Animals
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Arginine
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Binding Sites
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Enhancer Elements, Genetic
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Humans
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Models, Genetic
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Phosphorylation
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RNA Precursors / genetics*
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RNA Splicing*
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RNA, Messenger / genetics*
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RNA, Messenger / metabolism
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RNA-Binding Proteins / genetics*
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RNA-Binding Proteins / physiology
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Serine
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Spliceosomes / metabolism
Substances
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RNA Precursors
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RNA, Messenger
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RNA-Binding Proteins
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Serine
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Arginine